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MEMBRANE PROTEOME ARRAY™
Assess specificity and off-target binding of your biotherapeutic candidates. De-risk your program and choose the right lead molecule.
Membrane Proteome Array: The Leading Solution for Antibody Specificity Profiling
The Membrane Proteome Array is the leading solution for antibody specificity profiling. Our cell-based array contains the largest set of human membrane proteins (including heterocomplexes) assembled to determine specificity and preclinical safety of antibodies, CAR-T cell therapies, and other biotherapeutics.
“MPA technology quickly provided us with the reassurance that Abound Bio’s potent neutralizing antibodies to SARS-CoV-2 did not bind off-target human membrane proteins, which could be associated with toxicity.”
Applications: How you can use the Membrane Proteome Array
“We have been very pleased with the data that we obtained from the Membrane Proteome Array platform. This showed that our antibodies recognize only their select target, and not other membrane proteins in their panel.”
The MPA Advantage: What Makes the MPA so Successful
6,000 membrane proteins (including heterocomplexes)
representing >94% of the membrane proteome
High sensitivity flow cytometry detection, using unfixed cells to ensure native protein conformation and prevent false positives and negatives
Compatible with all biotherapeutics including monoclonal antibodies, scFv, VHH, bispecifics, peptides, and CAR-T cell therapies
4-week turnaround for IND-ready data package
with option for full traceability and auditability
with option for full traceability and auditability
Target validation by titration analysis
Successfully screened 1000+ molecules
Successfully screened 1000+ molecules
MPA Accepted into FDA’s ISTAND Program
Our MPA+IND service is the first Drug Development Tool to be considered under the FDA’s ISTAND Pilot Program. To learn more about this program, what’s next for us, and what it could mean for you, visit the link below.
Featured Case Studies
Publications Featuring the Membrane Proteome Array
MPA services are available directly through Integral Molecular or through our distributors
Frequently Asked Questions
What is the turnaround time for a Membrane Proteome Array project?
How does a Membrane Proteome Array project work?
What are the deliverables that I will receive upon completion of a project?
What binding conditions do you use for screening the Membrane Proteome Array?
How do you validate your hits?
What does the MPA’s qualification under the FDA’s ISTAND Program mean for me?
