Multi-spanning membrane proteins are targets of half of all small molecule drugs but only 3 therapeutic monoclonal antibodies (MAbs).
THE INDUSTRY LEADER IN MEMBRANE PROTEIN SOLUTIONS
Integral Molecular Publishes Mechanism of Claudin 6 Therapeutic Antibody
1/5/2023
Our Partner Context Therapeutics Nominates Lead Claudin 6 Molecule for Oncology Program
11/29/2022
New Product Lines of Safe Reporter Viruses for Vaccine Development and Pandemic Preparedness
10/20/2022
2nd GPCR – Targeted Drug Discovery Summit 2023
2/21 – 2/23 | Boston, MA
World Vaccine Congress US
4/3 – 4/6 | Washington, DC
AACR Annual Meeting 2023
4/14 – 4/19 | Orlando, Florida
Antibody specificity against highly conserved membrane protein Claudin 6 driven by single atomic contact point
iScience, 2022
Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses
Cell Host & Microbe, 2022
Broadly neutralizing antibodies target the coronavirus fusion peptide
Science, 2022
THE INDUSTRY LEADER IN MEMBRANE PROTEIN SOLUTIONS
Why Are There So Few Therapeutic Antibodies Against Complex Membrane Proteins?
MAbs offer therapeutic advantages of exquisite specificity, safety, and bioavailability and are twice as likely as small molecules to succeed in clinical trials. However, due to the complex structure and high homology of membrane protein targets, MAbs against them are difficult to generate, isolate and characterize.
Integral Molecular Enables Membrane Protein Antibody Discovery
With a 95% success rate, Integral Molecular is the leader in isolating MAbs against complex membrane proteins, including GPCRs, ion channels, transporters and viral proteins.
INDUSTRY EXPERIENCE
With 20+ years experience, Integral Molecular is the industry leader in isolating and characterizing complex membrane proteins.
PROVEN QUALITY
Integral Molecular’s technologies have contributed to scientific discoveries featured in 430+ peer-reviewed publications.
OPEN COMMUNICATION
Your success is crucial to us. We work hard to understand your needs, and strive to exceed your expectations.
Membrane Protein Solutions
Our full suite of Membrane Protein Solutions delivers diverse panels of functional MAbs
Our virus-like particles contain high levels of native membrane proteins for better immunization and screening
Our Ala-scan epitope mapping service provides mechanism of action data and strengthens IP
We screen antibodies against 6,000 human membrane proteins for deorphaning and de-risking studies
Reporter Virus Particles and other tools to expedite vaccine and antibody development
We offer licensing opportunities for therapeutic antibodies against untapped targets
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