Multi-spanning membrane proteins are targets of half of all small molecule drugs but only 3 therapeutic monoclonal antibodies (MAbs).
THE INDUSTRY LEADER IN MEMBRANE PROTEIN SOLUTIONS
Integral Molecular Publishes Mechanism of Claudin 6 Therapeutic Antibody
Our Partner Context Therapeutics Nominates Lead Claudin 6 Molecule for Oncology Program
New Product Lines of Safe Reporter Viruses for Vaccine Development and Pandemic Preparedness
Antibody specificity against highly conserved membrane protein Claudin 6 driven by single atomic contact point
Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses
Cell Host & Microbe, 2022
Broadly neutralizing antibodies target the coronavirus fusion peptide
Why Are There So Few Therapeutic Antibodies Against Complex Membrane Proteins?
MAbs offer therapeutic advantages of exquisite specificity, safety, and bioavailability and are twice as likely as small molecules to succeed in clinical trials. However, due to the complex structure and high homology of membrane protein targets, MAbs against them are difficult to generate, isolate and characterize.
Integral Molecular Enables Membrane Protein Antibody Discovery
With a 95% success rate, Integral Molecular is the leader in isolating MAbs against complex membrane proteins, including GPCRs, ion channels, transporters and viral proteins.
Integral Molecular’s technologies have contributed to scientific discoveries featured in 430+ peer-reviewed publications.
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Membrane Protein Solutions
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