Multi-spanning membrane proteins are targets of half of all small molecule drugs but only 3 therapeutic monoclonal antibodies (MAbs).
THE INDUSTRY LEADER IN MEMBRANE PROTEIN SOLUTIONS
Context Therapeutics and Integral Molecular Enter Collaboration and License Deal for Novel Claudin 6 Antibodies for Gynecologic Cancer Therapeutic Program
4/8/2021
Integral Molecular Enables Rapid Resistance Testing of Vaccines and Drugs Against Emerging Coronavirus Variants
2/4/21
Towards IND: Comprehensive specificity profiling of antibody-based therapies using the Membrane Proteome Array
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Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein
Cell, 2021
Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape
Nature Communications, 2021
THE INDUSTRY LEADER IN MEMBRANE PROTEIN SOLUTIONS
Why Are There So Few Therapeutic Antibodies Against Complex Membrane Proteins?
MAbs offer therapeutic advantages of exquisite specificity, safety, and bioavailability and are twice as likely as small molecules to succeed in clinical trials. However, due to the complex structure and high homology of membrane protein targets, MAbs against them are difficult to generate, isolate and characterize.
Integral Molecular Enables Membrane Protein Antibody Discovery
With a 95% success rate, Integral Molecular is the leader in isolating MAbs against complex membrane proteins, including GPCRs, ion channels, transporters and viral proteins.
INDUSTRY EXPERIENCE
With 15+ years experience, Integral Molecular is the industry leader in isolating and characterizing complex membrane proteins.
PROVEN QUALITY
Integral Molecular’s technologies have contributed to scientific discoveries featured in 200+ peer-reviewed publications.
OPEN COMMUNICATION
Your success is crucial to us. We work hard to understand your needs, and strive to exceed your expectations.
Membrane Protein Solutions
Our full suite of Membrane Protein Solutions delivers diverse panels of functional MAbs
Our virus-like particles contain high levels of native membrane proteins for better immunization and screening
Our Ala-scan epitope mapping service provides mechanism of action data and strengthens IP
We screen antibodies against 6,000 human membrane proteins for deorphaning and de-risking studies
We provide innovative tools, including Reporter Virus Technology, for rapid immunocharacterization
We offer licensing opportunities for therapeutic antibodies against untapped targets
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