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Integral Molecular Awarded Grant from the Commonwealth of Pennsylvania to Advance COVID-19 Research

PHILADELPHIA – Integral Molecular has been awarded $521,723 from the Commonwealth of Pennsylvania to leverage its technologies in the global fight against COVID-19. Integral Molecular is at the forefront of the fight against COVID-19, with their technologies being used by over 100 laboratories worldwide to advance COVID-19 vaccine and therapeutic development. This grant will enable Integral Molecular and its partners to develop therapeutics and vaccines with broad specificity against SARS-CoV-2 variants.

“As a founding member and leader in the Philadelphia biotechnology community, Integral Molecular brings 20 years of virology experience and unique tools to the fight against COVID-19,” said Christopher Molineaux, President and CEO of Life Sciences PA. “We are proud that the science being done in Pennsylvania is having an impact on a global scale.”

The scientific team at Integral Molecular has mobilized four of its technology platforms against the virus. This includes using its MPS Antibody Discovery platform to generate broadly reactive antibodies against SARS-CoV-2 and other coronaviruses. SARS-CoV-2 Reporter Virus Particles (RVPs) have been adopted by vaccine companies to safely test for neutralizing immune responses in patients and vaccinees. Integral Molecular’s Membrane Protein Array (MPA) is being used to rapidly screen the specificity of SARS-CoV-2 antibodies to advance the most promising candidates, and Shotgun Mutagenesis Epitope Mapping is being used to optimize vaccine and antibody design, so that resulting therapeutics and vaccines recognize emerging SARS-CoV-2 variants.

“Our technologies enable us to predict and test virus mutations that can result in resistance to treatments or vaccines,” said Benjamin Doranz, PhD, President and CEO of Integral Molecular. “Containing this pandemic is our immediate goal, but the challenge ahead is to prevent its recurrence in the future.”

Integral Molecular is honored to receive grant funding through the COVID-19 Vaccines, Treatments and Therapies (CV-VTT) program, administered by Dennis Davin, Secretary of the Department of Community and Economic Development (DCED) of the Commonwealth of Pennsylvania.

Science Center to Honor Leaders of Innovation Community at Annual Nucleus Awards

Benjamin Doranz Nucleus Award
PHILADELPHIA–(August 20, 2020) – The University City Science Center will recognize three local leaders during its annual Nucleus Awards event on September 22, 2020, presented by CSL Behring. This year’s class of honorees includes Benjamin Doranz, President & CEO of Integral Molecular, Aurora Archer, Founder & CEO of Bellatrix Group and Co-Host of The Opt-In Podcast, and Sylvester Mobley, CEO of Coded by Kids. The awards will be presented to the recipients during a one-hour virtual event hosted by WHYY’s Tracey Matisak.

Each fall, Nucleus brings together the region’s leaders and groundbreakers in innovation, all while supporting Philadelphia’s future as a hub of innovation and discovery. Funds raised through Nucleus help sustain Science Center programs, which in 2019 alone supported the growth of 118 businesses; convened more than 39,000 attendees across 475 events; and engaged over 370 middle and high school students through its STEM education initiatives.

“This year’s honorees exemplify the very best of what our region’s entrepreneurial ecosystem has to offer in our shared pursuit of improving the lives of people around the world,” says Bill Mezzanotte, M.D., M.P.H., Executive Vice President, Head of R&D and Chief Medical Officer for CSL Behring – company sponsor of this year’s Nucleus Awards – and member of the University City Science Center Board of Directors.

“Congratulations to Ben, Aurora and Sylvester for your outstanding examples of the tangible impact that novel technologies can have on quality of life, economic development and societal welfare.”

BENJAMIN DORANZ
President and CEO of Integral Molecular
Commercialization Award
Sponsored by NewSpring Capital

Ben Doranz is President and CEO of Integral Molecular. Founded in 2001 at the Science Center and current uCity Square resident, Integral Molecular is a founding member of the Philadelphia biotech community with a history of excellence in antibody discovery for difficult to treat diseases and research in emerging viruses. In 2020 Integral Molecular rapidly pivoted its research and development programs in an effort to combat the COVID-19 pandemic. With support from the National Institute of Health and a team of talented scientists, Integral Molecular rapidly adapted many of its platform technologies to launch a suite of research solutions to accelerate the development of SARS-CoV-2 therapeutics. These include Reporter Virus Particles (RVPs) to test for the presence of neutralizing antibodies in vaccinees and technologies to assess the breadth of human immune responses against this virus.

Dr. Doranz co-founded Integral Molecular together with colleagues from the University of Pennsylvania using virus-based technologies. He has led all aspects of the company’s growth since its inception, bringing five different technologies from research to market. His efforts have cultivated a company that is profitable while being actively engaged with the local community. Dr. Doranz is an established life science entrepreneur previously responsible for helping create startups at the Center for Technology Transfer at the University of Pennsylvania. Dr. Doranz earned a Ph.D. in Cellular and Molecular Biology from the University of Pennsylvania, an M.B.A. from the Wharton School of Business at the University of Pennsylvania, and a B.A. from Cornell University.

For more information about Nucleus or to purchase tickets, visit www.ucscNucleus.org.

Integral Molecular Develops Test for Neutralizing Antibodies in COVID-19 Patients and Clinical Trials

PHILADELPHIA – Integral Molecular announces the launch of SARS-CoV-2 Reporter Virus Particles (RVPs) to test patients for the presence of neutralizing antibodies, determine the effectiveness of vaccines, and measure the efficacy of drugs to enable expedited testing of new vaccines and therapeutics. As part of its commitment to supporting COVID-19 research, Integral Molecular will provide scientists with access to samples of SARS-CoV-2 RVPs at no cost.

Traditional diagnostic blood tests can only detect the presence or absence of antibodies. In contrast, SARS-CoV-2 RVPs assess the ability of antibodies to neutralize (block) virus infection. This distinction is crucial since neutralizing antibodies are the ones that typically offer protection from disease. SARS-CoV-2 RVPs eliminate the need to use live virus for neutralization assays and are safe using standard (BSL-2) laboratory conditions, quantitative, and amenable to high-throughput screening.

“With 20 years of virology experience, Integral Molecular is the industry leader in providing RVPs for therapeutic antibody development and vaccine clinical trials,” said Benjamin Doranz, President and CEO of Integral Molecular. “Like our other reporter viruses, we expect that coronavirus RVPs will be used to determine if serum from vaccinees contain protective antibodies, if new therapeutic antibodies can kill the virus, and if convalescent COVID-19 patients have protective serum that can be used in therapy.”

SARS-CoV-2 RVPs contain the coronavirus spike protein, which is the primary target of the human immune response, and carry a non-infectious genome that produces an easily measured fluorescent or light emitting signal upon cellular infection. Integral Molecular has extensive experience producing large-scale batches of quality-controlled RVPs for dengue and Zika viruses (Mattia et al., 2011, and Whitbeck et al., 2020), which are being used as critical reagents in vaccine clinical trials.

Integral Molecular has already begun shipping SARS-CoV-2 RVPs to partners, and will be discussing the SARS-CoV-2 reporter viruses at a webinar on May 12. Partners interested in using SARS-CoV-2 RVPs for their research or diagnostic assays should contact Integral Molecular.

About Integral Molecular
Integral Molecular (www.integralmolecular.com) is the industry leader in discovering and characterizing therapeutic antibodies against membrane proteins, an important group of drug targets found on the surfaces of cells and viruses. Integral Molecular’s technologies have been integrated into the drug discovery pipelines of over 300 biotech and pharmaceutical companies to help discover new therapies for cancer, diabetes, auto-immune disorders and viral threats such as SARS-CoV-2, Ebola, Zika, and dengue.

Integral Molecular Receives NIAID Award to Combat COVID-19

PHILADELPHIA – The National Institute of Allergy and Infectious Diseases (NIAID) has awarded Integral Molecular $1 million to enable the application of Integral Molecular’s technology platforms to aid in the discovery of vaccines and therapeutics to combat COVID-19.

Integral Molecular’s Shotgun Mutagenesis Epitope Mapping platform precisely identifies where antibodies bind to their target proteins, and will be used to design an improved vaccine and to identify the best therapeutic antibody candidates and combination cocktails.

SARS-CoV-2 Reporter Virus Particles are safe and non-replicating virus particles that display the coronavirus spike protein, the major viral protein targeted by the immune system. Reporter viruses provide developers an alternative to using live infectious virus, allowing antibodies, therapeutic drugs, and serum from vaccinated patients to be rapidly tested under safe laboratory conditions.

The company will use its Membrane Proteome Array platform of 6,000 human proteins to identify additional proteins that allow the virus to invade cells, helping to explain how the virus has been able to spread so quickly. The company’s Membrane Proteome Array platform has already been used to identify multiple receptors used by other viruses.

“We are pleased to support the scientific community around the world with our expertise and technologies in response to this pandemic,” said Benjamin Doranz, President and CEO of Integral Molecular. “We are fortunate to have financial support from NIAID to rapidly develop a suite of reagents and solutions that will make an impact on the speed of vaccine development and therapeutic testing.”

Integral Molecular has similarly responded to previous epidemics, including Zika, Ebola, and Chikungunya viruses. Since 2009, Integral has been awarded three consecutive contracts by NIAID to study viral immune responses, publishing over 50 virus-related publications including in high profile journals such as Cell and Nature.

This project has been funded by NIAID/NIH under Contract 75N93019C00073.

About Integral Molecular

Integral Molecular (www.integralmolecular.com) is the industry leader in discovering and characterizing therapeutic antibodies against membrane proteins, an important group of drug targets found on the surfaces of cells and viruses. Integral Molecular’s technologies have been integrated into the drug discovery pipelines of over 300 biotech and pharmaceutical companies to help discover new therapies for cancer, diabetes, auto-immune disorders and viral threats such as SARS-CoV-2, Ebola, Zika, and dengue.

Press Contact:
Integral Molecular Inc,
Soma Banik, PhD, Director of Communications
215-966-6061
info@integralmolecular.com
www.integralmolecular.com

Integral Molecular Accelerates Coronavirus Vaccine Research

PHILADELPHIA –Integral Molecular announces the mobilization of two of its key technology platforms to aid in the discovery of vaccines and therapeutics against the novel coronavirus which causes COVID-19. The company will use Shotgun Mutagenesis Epitope Mapping and the Membrane Proteome Array to understand the human immune response to the virus and identify cellular receptors that explain how the virus has been able to spread so quickly.

Integral Molecular has similarly responded to previous emerging epidemics, including Zika, Ebola and Chikungunya viruses, supporting vaccine and therapeutic discovery efforts throughout industry and academia. The company’s Shotgun Mutagenesis Epitope Mapping technology has been used to map over 1,000 antibody binding sites and is used throughout the vaccine industry. The company’s Membrane Proteome Array platform has already been used to identify multiple receptors used by viruses to enter and infect cells.

“Deep expertise in virology is at the core of Integral Molecular’s nearly 20-year history, including our contributions to discovering the receptor for HIV and other viruses,” said Benjamin Doranz, President of Integral Molecular. “We have the ability to use our unique tools to help curb the spread of this deadly virus and have initiated research efforts on multiple fronts to aid in the global effort for a coronavirus vaccine.”

About Integral Molecular

Integral Molecular (www.integralmolecular.com) is the industry leader in epitope mapping and antibody discovery, with a pipeline of therapeutic antibodies against GPCRs, ion channels, transporters, and immuno-oncology targets. Built on the company’s extensive experience optimizing membrane proteins, Integral Molecular’s technology suite enables the isolation, characterization, and engineering of MAbs against otherwise intractable targets. The company currently has therapeutic programs focused on cancer, pain, immunity, and metabolic diseases

Press Contact:
Integral Molecular Inc,
Soma Banik, PhD, Director of Communications
215-966-6061
info@integralmolecular.com
www.integralmolecular.com

Integral Molecular Launches ReadyMap Services for Rapid, Conformational Epitope Mapping

PHILADELPHIA –Integral Molecular, the industry leader in the discovery and characterization of antibodies against membrane proteins, announces the launch of ReadyMap services, an expansion of its Shotgun Mutagenesis Epitope Mapping platform for rapid mapping of antibody binding sites on pre-validated protein targets.

Epitope mapping enhances antibody intellectual property and enables informed lead selection for antibodies by revealing their mechanisms of action. With its 4-week turnaround time, ReadyMap services allow conformational epitope mapping to be used early in the antibody discovery process for lead selection.

Integral Molecular’s first ReadyMap alanine-scan libraries address the needs of cancer researchers working on HER2, HER3, and PD-L1. Integral Molecular also continues to offer custom Shotgun Mutagenesis epitope mapping services for any protein target.

Integral Molecular is a trusted partner to numerous companies as well as the NIH, mapping over 1,000 epitopes with a 95% success rate. Shotgun Mutagenesis epitope mapping data have been featured in over 40 patents and 100 publications, many in high-profile journals such as Cell, Nature and PNAS.

“Our epitope mapping technology has been instrumental in the detailed characterization and protection of antibody assets,” said Sharon Willis, VP of Sales and Customer Relations. “We understand that our customers benefit from faster epitope data to inform antibody selection, and our ReadyMap services provide this, even for conformational antibodies and difficult targets.”

About Integral Molecular

Integral Molecular (www.integralmolecular.com) is the industry leader in epitope mapping and antibody discovery, with a pipeline of therapeutic antibodies against GPCRs, ion channels, transporters, and immuno-oncology targets. Built on the company’s extensive experience optimizing membrane proteins, Integral Molecular’s technology suite enables the isolation, characterization, and engineering of MAbs against otherwise intractable targets. The company currently has therapeutic programs focused on cancer, pain, immunity, and metabolic diseases

Press Contact:
Integral Molecular Inc,
Soma Banik, PhD, Director of Communications
215-966-6061
info@integralmolecular.com
www.integralmolecular.com

Integral Molecular Announces Preclinical P2X7 Antibody Assets for Autoimmune Disorders

PHILADELPHIA – Integral Molecular, the leader in discovering antibodies against multipass membrane proteins, announces lead monoclonal antibodies (MAbs) against P2X7, a structurally complex ion channel that is the target for autoimmune disorders including atopic dermatitis and glomerulonephritis. The panel of P2X7 antibodies is fully humanized and optimized, and ready to progress towards preclinical studies.

The P2X7 ion channel target is involved in regulating a population of T cells that drive multiple autoimmune diseases. However, the target has been largely refractory to antibody discovery efforts due to its complex structure.

“Despite its important role in the pathway of many diseases, there are no existing drugs against P2X7,” said Ross Chambers, VP of Antibody Discovery. “Our MPS Antibody Discovery platform was built to handle complex membrane protein targets such as P2X7 and has enabled us to isolate high-affinity antibodies in the picomolar range that exhibit antagonist or rare agonist activity.“

Integral Molecular’s MPS Antibody Discovery platform encompasses a comprehensive technology suite that overcomes the obstacles of working with highly conserved and structurally complex membrane protein targets, including antigen engineering and presentation on Lipoparticles, immunization of divergent species, and deep screening techniques such as B-cell cloning to recover rare antibodies.

Integral Molecular will discuss its antibody assets in immune modulation, oncology, and metabolic disease at the upcoming JP Morgan Conference taking place from January 13-16, 2020 in San Francisco, California. The company is currently isolating MAbs against dozens of membrane protein targets and welcomes antibody out licensing opportunities and discovery partnerships.

About Integral Molecular
Integral Molecular (www.integralmolecular.com) is the industry leader in epitope mapping and antibody discovery, with a pipeline of therapeutic antibodies against GPCRs, ion channels, transporters, and immuno-oncology targets. Built on the company’s extensive experience optimizing membrane proteins, Integral Molecular’s technology suite enables the isolation, characterization, and engineering of MAbs against otherwise intractable targets. The company currently has therapeutic programs focused on cancer, pain, immunity, and metabolic diseases.

Contact:
Integral Molecular, Inc.
Soma Banik
Director of Scientific Communications
215-966-6061
info@integralmolecular.com

Integral Molecular to Advance Vaccine Discovery with NIH Contract for $5.5M

PHILADELPHIA – (PR NEWSWIRE) – The National Institute of Allergy and Infectious Diseases (NIAID) has awarded Integral Molecular a contract (75N93019C00073) which will provide up to $5.5M over the next five years to define antibody responses to pathogenic viruses including Zika, Marburg and equine encephalitis viruses (EEV), aiding the discovery of vaccines and therapeutics against these currently untreatable and often lethal viruses.

With this third competitive contract award, NIAID, part of the National Institutes of Health (NIH), has recognized Integral Molecular’s achievements in using epitope mapping to understand the human immune response to viruses. This research is being conducted in collaboration with Dr. James Crowe, Director of the Vanderbilt Vaccine Center.

“Our nearly 20 year experience studying pathogenic viruses including Dengue, Chikungunya, Hepatitis C, Zika, and Ebola has expanded our understanding of how antibodies can provide protection from viruses” said Benjamin Doranz, CEO of Integral Molecular and Principal Investigator of the contract. “This continued support from NIAID validates our approach, allows us to broaden the scope of our studies, and will yield new insights that provide effective therapeutics and vaccines against these deadly viruses.”

Integral Molecular’s Shotgun Mutagenesis epitope mapping technology has provided powerful insights that have contributed to over 40 manuscripts in high impact journals including Cell, Nature and Immunity. Shotgun Mutagenesis epitope mapping has been used to map over 1,000 antibody binding sites to generate mechanistic insights and intellectual property, and is used throughout the vaccine industry.

About Integral Molecular
Integral Molecular (www.integralmolecular.com) is the industry leader in epitope mapping and antibody discovery, with a pipeline of therapeutic antibodies against GPCRs, ion channels, transporters, and immuno-oncology targets. Built on the company’s extensive experience optimizing membrane proteins, Integral Molecular’s technology suite enables the isolation, characterization, and engineering of MAbs against otherwise intractable targets. The company currently has therapeutic programs focused on cancer, pain, immunity, and metabolic diseases.

Contact:
Integral Molecular, Inc.
Soma Banik
Director of Scientific Communications
215-966-6061
info@integralmolecular.com