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Where research scientists come to find up to date resources on antibody discovery against challenging membrane protein targets.

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Integral Molecular Accelerates Coronavirus Vaccine Research

PHILADELPHIA –Integral Molecular announces the mobilization of two of its key technology platforms to aid in the discovery of vaccines and therapeutics against the novel coronavirus which causes COVID-19. The company will use Shotgun Mutagenesis Epitope Mapping and the Membrane Proteome Array to understand the human immune response to the virus and identify cellular receptors that explain how the virus has been able to spread so quickly.

Integral Molecular has similarly responded to previous emerging epidemics, including Zika, Ebola and Chikungunya viruses, supporting vaccine and therapeutic discovery efforts throughout industry and academia. The company’s Shotgun Mutagenesis Epitope Mapping technology has been used to map over 1,000 antibody binding sites and is used throughout the vaccine industry. The company’s Membrane Proteome Array platform has already been used to identify multiple receptors used by viruses to enter and infect cells.

“Deep expertise in virology is at the core of Integral Molecular’s nearly 20-year history, including our contributions to discovering the receptor for HIV and other viruses,” said Benjamin Doranz, President of Integral Molecular. “We have the ability to use our unique tools to help curb the spread of this deadly virus and have initiated research efforts on multiple fronts to aid in the global effort for a coronavirus vaccine.”

About Integral Molecular

Integral Molecular (www.integralmolecular.com) is the industry leader in epitope mapping and antibody discovery, with a pipeline of therapeutic antibodies against GPCRs, ion channels, transporters, and immuno-oncology targets. Built on the company’s extensive experience optimizing membrane proteins, Integral Molecular’s technology suite enables the isolation, characterization, and engineering of MAbs against otherwise intractable targets. The company currently has therapeutic programs focused on cancer, pain, immunity, and metabolic diseases

Press Contact:
Integral Molecular Inc,
Soma Banik, PhD, Director of Communications
215-966-6061
info@integralmolecular.com
www.integralmolecular.com

Integral Molecular Launches ReadyMap Services for Rapid, Conformational Epitope Mapping

PHILADELPHIA –Integral Molecular, the industry leader in the discovery and characterization of antibodies against membrane proteins, announces the launch of ReadyMap services, an expansion of its Shotgun Mutagenesis Epitope Mapping platform for rapid mapping of antibody binding sites on pre-validated protein targets.

Epitope mapping enhances antibody intellectual property and enables informed lead selection for antibodies by revealing their mechanisms of action. With its 4-week turnaround time, ReadyMap services allow conformational epitope mapping to be used early in the antibody discovery process for lead selection.

Integral Molecular’s first ReadyMap alanine-scan libraries address the needs of cancer researchers working on HER2, HER3, and PD-L1. Integral Molecular also continues to offer custom Shotgun Mutagenesis epitope mapping services for any protein target.

Integral Molecular is a trusted partner to numerous companies as well as the NIH, mapping over 1,000 epitopes with a 95% success rate. Shotgun Mutagenesis epitope mapping data have been featured in over 40 patents and 100 publications, many in high-profile journals such as Cell, Nature and PNAS.

“Our epitope mapping technology has been instrumental in the detailed characterization and protection of antibody assets,” said Sharon Willis, VP of Sales and Customer Relations. “We understand that our customers benefit from faster epitope data to inform antibody selection, and our ReadyMap services provide this, even for conformational antibodies and difficult targets.”

About Integral Molecular

Integral Molecular (www.integralmolecular.com) is the industry leader in epitope mapping and antibody discovery, with a pipeline of therapeutic antibodies against GPCRs, ion channels, transporters, and immuno-oncology targets. Built on the company’s extensive experience optimizing membrane proteins, Integral Molecular’s technology suite enables the isolation, characterization, and engineering of MAbs against otherwise intractable targets. The company currently has therapeutic programs focused on cancer, pain, immunity, and metabolic diseases

Press Contact:
Integral Molecular Inc,
Soma Banik, PhD, Director of Communications
215-966-6061
info@integralmolecular.com
www.integralmolecular.com

Integral Molecular Announces Preclinical P2X7 Antibody Assets for Autoimmune Disorders

PHILADELPHIA – Integral Molecular, the leader in discovering antibodies against multipass membrane proteins, announces lead monoclonal antibodies (MAbs) against P2X7, a structurally complex ion channel that is the target for autoimmune disorders including atopic dermatitis and glomerulonephritis. The panel of P2X7 antibodies is fully humanized and optimized, and ready to progress towards preclinical studies.

The P2X7 ion channel target is involved in regulating a population of T cells that drive multiple autoimmune diseases. However, the target has been largely refractory to antibody discovery efforts due to its complex structure.

“Despite its important role in the pathway of many diseases, there are no existing drugs against P2X7,” said Ross Chambers, VP of Antibody Discovery. “Our MPS Antibody Discovery platform was built to handle complex membrane protein targets such as P2X7 and has enabled us to isolate high-affinity antibodies in the picomolar range that exhibit antagonist or rare agonist activity.“

Integral Molecular’s MPS Antibody Discovery platform encompasses a comprehensive technology suite that overcomes the obstacles of working with highly conserved and structurally complex membrane protein targets, including antigen engineering and presentation on Lipoparticles, immunization of divergent species, and deep screening techniques such as B-cell cloning to recover rare antibodies.

Integral Molecular will discuss its antibody assets in immune modulation, oncology, and metabolic disease at the upcoming JP Morgan Conference taking place from January 13-16, 2020 in San Francisco, California. The company is currently isolating MAbs against dozens of membrane protein targets and welcomes antibody out licensing opportunities and discovery partnerships.

About Integral Molecular
Integral Molecular (www.integralmolecular.com) is the industry leader in epitope mapping and antibody discovery, with a pipeline of therapeutic antibodies against GPCRs, ion channels, transporters, and immuno-oncology targets. Built on the company’s extensive experience optimizing membrane proteins, Integral Molecular’s technology suite enables the isolation, characterization, and engineering of MAbs against otherwise intractable targets. The company currently has therapeutic programs focused on cancer, pain, immunity, and metabolic diseases.

Contact:
Integral Molecular, Inc.
Soma Banik
Director of Scientific Communications
215-966-6061
info@integralmolecular.com

Integral Molecular to Advance Vaccine Discovery with NIH Contract for $5.5M

PHILADELPHIA – (PR NEWSWIRE) – The National Institute of Allergy and Infectious Diseases (NIAID) has awarded Integral Molecular a contract (75N93019C00073) which will provide up to $5.5M over the next five years to define antibody responses to pathogenic viruses including Zika, Marburg and equine encephalitis viruses (EEV), aiding the discovery of vaccines and therapeutics against these currently untreatable and often lethal viruses.

With this third competitive contract award, NIAID, part of the National Institutes of Health (NIH), has recognized Integral Molecular’s achievements in using epitope mapping to understand the human immune response to viruses. This research is being conducted in collaboration with Dr. James Crowe, Director of the Vanderbilt Vaccine Center.

“Our nearly 20 year experience studying pathogenic viruses including Dengue, Chikungunya, Hepatitis C, Zika, and Ebola has expanded our understanding of how antibodies can provide protection from viruses” said Benjamin Doranz, CEO of Integral Molecular and Principal Investigator of the contract. “This continued support from NIAID validates our approach, allows us to broaden the scope of our studies, and will yield new insights that provide effective therapeutics and vaccines against these deadly viruses.”

Integral Molecular’s Shotgun Mutagenesis epitope mapping technology has provided powerful insights that have contributed to over 40 manuscripts in high impact journals including Cell, Nature and Immunity. Shotgun Mutagenesis epitope mapping has been used to map over 1,000 antibody binding sites to generate mechanistic insights and intellectual property, and is used throughout the vaccine industry.

About Integral Molecular
Integral Molecular (www.integralmolecular.com) is the industry leader in epitope mapping and antibody discovery, with a pipeline of therapeutic antibodies against GPCRs, ion channels, transporters, and immuno-oncology targets. Built on the company’s extensive experience optimizing membrane proteins, Integral Molecular’s technology suite enables the isolation, characterization, and engineering of MAbs against otherwise intractable targets. The company currently has therapeutic programs focused on cancer, pain, immunity, and metabolic diseases.

Contact:
Integral Molecular, Inc.
Soma Banik
Director of Scientific Communications
215-966-6061
info@integralmolecular.com