PROTEIN ENGINEERING

Harness Integral Molecular’s 20+ years of protein engineering experience to improve gene therapy

10x to 100x improvements

4 deep screening platforms

10³ to 10⁹ variants screened

How can protein engineering improve gene therapy transgenes?

GeneCanvas

GeneCanvas™ provides a multi-faceted approach to protein engineering

✓Increase expression (learn more)

✓Increase stability (learn more)

✓Increase activity

✓Improve trafficking

10x to 100x improvements

Integral Molecular’s GeneCanvas advantage

Our scientists bring an unrivaled combination of deep protein engineering expertise and a diverse toolkit to develop a customized strategy for each engineering challenge

4 deep screening platforms including high-throughput Shotgun Mutagenesis ™, Comprehensive Affinity Mutagenesis(CAM ™), flow sorting, and phage screening

20+ years experience engineering the most difficult proteins, including ion channels, transporters, GPCRs, viral proteins, and enzymes

100s of proteins (antibodies, viruses, transgenes) optimized for affinity, activity, and specificity

10³ to 10⁹ variants screened using high-throughput capabilities and in silico structural analyses

430+ papers and patents published using Integral Molecular technologies; engineering expertise used throughout the biopharmaceutical industry

Integral Molecular’s GeneCanvas engineering technologies

We conduct a detailed analysis of each target to determine the optimal approach for protein engineering and to develop a customized work plan for our partners

Shotgun Mutagenesis
Using our shotgun mutagenesis high-throughput mutagenesis and comprehensive affinity mutagenesis, we create thousands of targeted mutations and screen them for binding or functional activity in human cells

High-throughput Flow Cytometry and Cell Sorting
We produce millions of variants by random mutagenesis and use flow cytometry for rapid and high-sensitivity assessment of binding in live human cells

Comprehensive Affinity Maturation
We generate a library of thousands of mutations in bacteria using proprietary technologies and screen the variants for optimal activity

Phage Panning
Using specialized phage protocols, we select variants from libraries of up to 10⁹complexity that display high-affinity binding

Ready To Get Started?

We have worked with more than 100 top biotech and pharmaceutical companies to help them succeed. Let’s talk about how we can help you.

Or call (215) 966-6061

PROTEIN ENGINEERING

How can protein engineering improve gene therapy transgenes?

GeneCanvas

GeneCanvas™ provides a multi-faceted approach to protein engineering

Integral Molecular’s GeneCanvas advantage

Our scientists bring an unrivaled combination of deep protein engineering expertise and a diverse toolkit to develop a customized strategy for each engineering challenge

4 deep screening platforms including high-throughput Shotgun Mutagenesis ™, Comprehensive Affinity Mutagenesis(CAM ™), flow sorting, and phage screening

20+ years experience engineering the most difficult proteins, including ion channels, transporters, GPCRs, viral proteins, and enzymes

100s of proteins (antibodies, viruses, transgenes) optimized for affinity, activity, and specificity

10³ to 10⁹ variants screened using high-throughput capabilities and in silico structural analyses

Integral Molecular’s GeneCanvas engineering technologies

We conduct a detailed analysis of each target to determine the optimal approach for protein engineering and to develop a customized work plan for our partners

Shotgun Mutagenesis
Using our shotgun mutagenesis high-throughput mutagenesis and comprehensive affinity mutagenesis, we create thousands of targeted mutations and screen them for binding or functional activity in human cells

High-throughput Flow Cytometry and Cell Sorting
We produce millions of variants by random mutagenesis and use flow cytometry for rapid and high-sensitivity assessment of binding in live human cells

Comprehensive Affinity Maturation
We generate a library of thousands of mutations in bacteria using proprietary technologies and screen the variants for optimal activity

Phage Panning
Using specialized phage protocols, we select variants from libraries of up to 10⁹complexity that display high-affinity binding

Ready To Get Started?

Quick Links

Solutions

Contact Us

PROTEIN ENGINEERING​

How can protein engineering improve gene therapy transgenes?

GeneCanvas

GeneCanvas™ provides a multi-faceted approach to protein engineering

Integral Molecular’s GeneCanvas advantage

Our scientists bring an unrivaled combination of deep protein engineering expertise and a diverse toolkit to develop a customized strategy for each engineering challenge

4 deep screening platforms including high-throughput Shotgun Mutagenesis ™, Comprehensive Affinity Mutagenesis(CAM ™), flow sorting, and phage screening

20+ years experience engineering the most difficult proteins, including ion channels, transporters, GPCRs, viral proteins, and enzymes

100s of proteins (antibodies, viruses, transgenes) optimized for affinity, activity, and specificity

103 to 109 variants screened using high-throughput capabilities and in silico structural analyses

Integral Molecular’s GeneCanvas engineering technologies

We conduct a detailed analysis of each target to determine the optimal approach for protein engineering and to develop a customized work plan for our partners

Shotgun MutagenesisUsing our shotgun mutagenesis high-throughput mutagenesis and comprehensive affinity mutagenesis, we create thousands of targeted mutations and screen them for binding or functional activity in human cells

High-throughput Flow Cytometry and Cell SortingWe produce millions of variants by random mutagenesis and use flow cytometry for rapid and high-sensitivity assessment of binding in live human cells

Comprehensive Affinity MaturationWe generate a library of thousands of mutations in bacteria using proprietary technologies and screen the variants for optimal activity

Phage PanningUsing specialized phage protocols, we select variants from libraries of up to 109 complexity that display high-affinity binding

Ready To Get Started?

Quick Links

Solutions

Contact Us

PROTEIN ENGINEERING

10³ to 10⁹ variants screened using high-throughput capabilities and in silico structural analyses

Shotgun Mutagenesis
Using our shotgun mutagenesis high-throughput mutagenesis and comprehensive affinity mutagenesis, we create thousands of targeted mutations and screen them for binding or functional activity in human cells

High-throughput Flow Cytometry and Cell Sorting
We produce millions of variants by random mutagenesis and use flow cytometry for rapid and high-sensitivity assessment of binding in live human cells

Comprehensive Affinity Maturation
We generate a library of thousands of mutations in bacteria using proprietary technologies and screen the variants for optimal activity

Phage Panning
Using specialized phage protocols, we select variants from libraries of up to 10⁹complexity that display high-affinity binding