Lower IgG somatic hypermutation rates during acute dengue virus infection is compatible with a germinal center-independent B cell response
GODOY-LOZANO ET AL. 2016. GENOME MED 8(1):23.
RESOURCES
Where research scientists come to find up to date resources on antibody discovery against challenging membrane protein targets.
Category: Mapping and Engineering
Cryo-EM structures Elucidate Neutralizing Mechanisms of anti-Chikungunya Human Monoclonal Antibodies with Therapeutic Activity.
LONG ET AL. 2015. PNAS 112(45):13898-13903.
Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress.
FOX ET AL. 2015. CELL 163(5):1095-1107.
Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus.
SMITH ET AL. 2015. CELL HOST MICROBE 18(1):86-95.
Potent and Efficacious Inhibition of CXCR2 Signaling by Biparatopic Nanobodies Combining Two Distinct Modes of Action
BRADLEY ET AL. 2015. MOL PHARMACOL (87):251–262.
HCV E2 core structures and mAbs: something is still missing
CASTELLI ET AL. 2014. DRUG DISCOVERY TODAY 19(12):1964-1970.
Functional Analysis of Antibodies against Dengue Virus Type 4 Reveals Strain-Dependent Epitope Exposure That Impacts Neutralization and Protection.
SUKUPOLVI-PETTY ET AL. 2013. JOURNAL OF VIROLOGY 87(16):8826-8842.
Atomic-level functional model of dengue virus Envelope protein infectivity.
CHRISTIAN ET AL. 2013. PNAS 110(46):18667.
Maximal Humanization of Monoclonal Abs.
BERDOUGO ET AL. 2011. GENETIC ENGINEERING & BIOTECHNOLOGY NEWS VOL. 31, NO. 14.