Thursday, October 29, 2020
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Integral Molecular has a 95% success rate of discovering high-affinity monoclonal antibodies against multipass membrane proteins despite the structural complexity and low immunogenicity of these targets. Here, we present some of the lessons we have learned throughout numerous discovery campaigns against these historically intractable targets, including GPCRs, ion channels and transporters.
What you’ll learn:
The 6 key steps to success in discovering high-quality, functional MAbs
How to use Lipoparticles with native-conformation antigen for effective immunization, screening and panning
How to access conserved and difficult epitopes