Neutralizing Monoclonal Antibodies Block Chikungunya Virus Entry and Release by Targeting an Epitope Critical to Viral Pathogenesis
JIN ET AL. 2016. CELL REPORTS 13(11): 2553-2564.
RESOURCES
Where research scientists come to find up to date resources on antibody discovery against challenging membrane protein targets.
Category: Virology
Rapid isolation of dengue-neutralizing antibodies from single cell-sorted human antigen-specific memory B-cell cultures
COX ET AL. 2016. MABS 8(1):129-140.
Integral Molecular Sizes Up Ebola:Membrane Protein Specialist Maps Ebola’s Binding Sites to Advance Vaccine Discovery.
DUTTON 2016. GENETIC ENGINEERING NEWS VOL. 36, NO. 1.
Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice
SAPPARAPU ET AL. 2016. NATURE 540, 443–447.
Lower IgG somatic hypermutation rates during acute dengue virus infection is compatible with a germinal center-independent B cell response
GODOY-LOZANO ET AL. 2016. GENOME MED 8(1):23.
Cryo-EM structures Elucidate Neutralizing Mechanisms of anti-Chikungunya Human Monoclonal Antibodies with Therapeutic Activity.
LONG ET AL. 2015. PNAS 112(45):13898-13903.
Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress.
FOX ET AL. 2015. CELL 163(5):1095-1107.
Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus.
SMITH ET AL. 2015. CELL HOST MICROBE 18(1):86-95.
HCV E2 core structures and mAbs: something is still missing
CASTELLI ET AL. 2014. DRUG DISCOVERY TODAY 19(12):1964-1970.