REPORTER VIRUS PARTICLES

Pseudotyped and virus-like particles for neutralization assays: reagents for antibody and vaccine development

Critical virology reagents

20+ years virology expertise

Trusted by 100+ labs

Non-Replicative Virus Particles for Safe Neutralization Assays

Integral Molecular® Reporter Virus Particles (RVPs) are for scientists working to develop vaccines, antibodies, and other countermeasures against the world’s deadliest and most challenging viruses.

RVPs are non-replicative virus-like particles with surface proteins from a diverse range of viruses. They are a safe, ready-to-use substitute for live virus, ideal for infectivity and neutralization assays.

Built on a foundation of 20+ years’ virology experience, RVPs meet high quality standards, and they’re easy to use with standard instruments.
Cross-section schematic of pseudotyped lentiviral RVP. Viral envelope proteins stud the surface of a spherical lipid bilayer. Inside, a lentivirus heterologous core surrounds a reporter gene. Graph shows a SARS-CoV-2 pseudovirus neutralization assay, comparing serum from two patients against positive control monoclonal antibody and negative control serum.

Product Offerings: The Most Extensive Catalog of Pseudotyped & Virus-like Particles

Reporter virus particle schematics show an overview of available products. Coronavirus, including SARS-CoV-2 variants; influenza A and B in seasonal and pandemic strains; Ebola and Marburg filoviruses; Alphaviruses; Lassa arenavirus; henipavirus; flavivirus, including Zika, Dengue, and yellow fever; and custom reporter viruses.
Cross-section schematics of RVP pseudoviruses for neutralization assays. Includes multiple coronaviruses, Influenza A and B, Filovirus, Henipavirus, Dengue, and Zika.

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Reporter Virus Particle Catalog

Pseudotyped and pseudoinfective particles for virology and vaccine discovery

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Target cell lines, neutralizing antibodies, and control pseudoviral particles for your RVP research
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Pseudotyped and pseudoinfective particles for virology and vaccine discovery

View RVP Catalog >>

Target cell lines, neutralizing antibodies, and control pseudoviral particles for your RVP research
View Product Catalog >>

Other offerings, including TiterSafe for HAI assays, neutralization assay services, and more
Virology Products & Services >>

Reporter Virus Particle Catalog

Pseudotyped and pseudoinfective particles for virology and vaccine discovery

View RVP Catalog >>

Products to Use with Reporter Virus Particles

Target cell lines, neutralizing antibodies, and control pseudoviral particles for your RVP research
View Product Catalog >>

More Virology Products & Services

Other offerings, including TiterSafe for HAI assays, neutralization assay services, and more
Virology Products & Services >>

“There are some hurdles to running live virus neutralization assays. RVPs made it easy to triage leads across many viral variants. The luciferase RVP assay was very easy to run, and it helped us identify mAbs with neutralizing activity against all the variants we tried.”

Case Studies: See how our customers have used RVPs ​

To see more case studies, plus publications and webinars, visit the Resources page

Reporter Virus Particles are available directly through Integral Molecular or through our partner distributors.

Publications Establishing RVPs as a Critical Reagent

Featured White Paper: Using Pseudoviruses in Neutralization Assays

Learn why virologists are increasingly turning to pseudoviruses as an alternative to live virus.

Download the white paper

White paper cover page reads, Using Pseudoviruses in Neutralization Assays Volume 1: Current Viral Models & Applications

Frequently Asked Questions

RVPs incorporate virus-specific envelope proteins that are antigenically equivalent to those of live wild-type viruses. They contain a modified genome and so are replication-incompetent and safe to use under standard safety levels (BSL-2). Once the RVPs are in your hands, you can begin your neutralization assays immediately – no need for growing and sequencing live virus.
RVPs are used for infectivity and neutralization assays, and are ideal for use in high-throughput assay formats. They are a safe (BSL-2) and efficient alternative to live virus plaque or microneutralization assays. Many customers use our RVPs to conduct sera neutralization assays to assess efficacy of their vaccine or vaccine candidate.
Luciferase and GFP are used for quantitative readouts.

Integral Molecular offers many vaccine development solutions including the production of reporter viruses, epitope mapping on viral targets, protein engineering for vaccine discovery, and antibody discovery against viral targets.

Yes. We can produce custom RVPs to accelerate your vaccine or antibody development project, with variants of current RVPs, or for a virus of your choice. We have a team of expert scientists that acts as your partner from project initiation to delivery of RVPs. Our customized quality control services and reports meet the specific needs of your team and project.

Yes. We can produce large lots of RVPs to accommodate screening 100s or 1000s of samples in sera neutralization assays without bridging studies.

Request more information about Reporter Virus Particles