REPORTER VIRUS PARTICLE CATALOG

Pseudotyped and pseudoinfective reporter viruses for
virology and vaccine discovery

Reporter Viruses

Epitope Mapping
MAb Specificity Testing

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Coronavirus   |    Influenza   |      Filovirus    |   Arbovirus   |   Henipavirus  |   Arenavirus  |   Contact Us |   FAQs

The most extensive catalog of Reporter Virus Particles (RVPs)

Reporter Virus Particles (RVPs) are replication-incompetent pseudovirus particles that enable safe (BSL-2), easy, and high-throughput viral infectivity and neutralization assays using standard detection instrumentation. To learn more about RVPs, visit Virology: Pseudotyped Reporter Virus Particles

We regularly add new products to our catalog. To receive updates on our product offerings, join our mailing list.

We also offer target cell lines, neutralizing antibodies, and control viral particles to use in your RVP research.

Coronavirus

Our extensive catalog of SARS-CoV-2 variants manufactured with rigorous quality control can help your discovery program meet FDA guidances  for COVID-19 vaccines and therapeutics

For more information about these products, visit SARS-CoV-2 Variant Reporter Viruses

Emergent Variant SARS-CoV-2 RVPs

Catalog No. (G/L*)
SARS-CoV-2 / Variant
WHO
Mutations
RVP-702
D614G B.1, 20A
———
D614G
RVP-701
Wuhan-Hu-1
———
Reference seq (GenBank QHD43416.1)
RVP-768
B.1.1.529.1, BA.1
Omicron
A67V, Δ69-70, T95I, G142D/Δ143-145, Δ211/L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F
RVP-771
B.1.1.529.1.1, BA.1.1
Omicron
A67V, Δ 69-70, T95I, Δ 142-144, Y145D, Δ 211, L212I, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F
RVP-770
B.1.1.529.2, BA.2
Omicron
T19I, Δ24-26, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
RVP-775
B.1.1.529.2.12.1, BA.2.12.1
Omicron
T19I, LPPA24S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452Q, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K
RVP-776
B.1.1.529.2.75, BA.2.75
Omicron
T19I, LPPA24S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339R, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
RVP-794
BA.2.86
Omicron
T19I, R21T, LPPA24S, S50L, HV69del, V127F, G142D, Y144-, F157S, R158G, NL211I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F,T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L
RVP-774
B.1.1.529.4/5, BA.4/BA.5
Omicron
T19I, LPPA24S, HV69del, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
RVP-777
B.1.1.529.4.6, BA.4.6
Omicron
T19I, LPPA24S, HV69del, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, N764K, D796Y, Q954H, N969K
RVP-779
BF.7
Omicron
T19I, LPPA24S, HV69del, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
RVP-785
BQ.1
Omicron
T19I, LPPA24S, HV69del, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
RVP-782
BQ.1.1
Omicron
T19I, LPPA24S, HV69del, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
RVP-787
CH.1.1
Omicron
T19I, LPPA24S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
RVP-792
EG.5
Omicron
T19I, LPPA24S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
RVP-791
EG.5.1
Omicron
T19I, LPPA24S, Q52H, V83A, G142D, Y144del, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
RVP-793
FL.1.5.1
Omicron
T19I, LPPA24S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K
RVP-795
HV.1
Omicron
T19I, LPPA24S, Q52H, V83A, G142D, Y144del, H146Q, F157L, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P,S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L452R, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
RVP-796
JN.1
Omicron
T19I, R21T, LPPA24S, S50L, HV69del, V127F, G142D, Y144-, F157S, R158G, NL211I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L
RVP-780
XBB.1
Omicron
T19I, LPPA24S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
RVP-786
XBB.1.5/XBB.1.9.1
Omicron
T19I, LPPA24S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
RVP-789
XBB.1.16
Omicron
T19I, LPPA24S, V83A, G142D, Y144del, H146Q,E180V, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
RVP-790
XBB.2.3
Omicron
T19I, LPPA24S, V83A, G142D, Y144del, H146Q, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
RVP-788
XBF
Omicron
T19I, LPPA24S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K
Catalog No. (G/L*)
SARS-CoV-2 / Variant
WHO
Mutations
RVP-717
UK variant B.1.1.7 with E484K
———
ΔH69/V70, ΔY144, E484K, N501Y, A570D, P681H, T716I, S982A, D1118H
RVP-724
South African variant Δ3 B.1.351, 20H/501Y.V2
Beta
L18F, D80A, D215G, ΔL242/A243/L244, R246I, K417N, N501Y, E484K, A701V
RVP-708
Brazilian variant P.1, 20J/501Y.V3
Gamma
L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, V1176F
RVP-713
Californian variant B.1.427/B.1.429, 20C/452R
Epsilon
S13I, W152C, L452R

*All RVPs are available with a GFP (G) or luciferase (L) reporter. Please add G/L to the catalog number when ordering to indicate the preferred reporter gene.

Custom SARS-CoV-2 RVP variants and RVPs from our library of 1,200 alanine spike mutants are available upon request. Please contact us for pricing.

Learn more about how pseudoviruses meet FDA guidances

 

More SARS-CoV-2 Variant RVPs

Catalog No. (G/L)
SARS-CoV-2 RVPs / Variants
WHO
Mutations
RVP-706
UK variant B.1.1.7, 20I/501Y.V1
Alpha
ΔH69/V70, ΔY144, N501Y, A570D, P681H, T716I, S982A, D1118H
RVP-707
South African variant B.1.351, 20C/501Y.V2
———
L18F, D80A, D215G, L242H, R246I, K417N, N501Y, E484K, A701V
RVP-708
Brazilian variant P.1, 20J/501Y.V3
Gamma
L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, V1176Ft
RVP-713
Californian variant B.1.427/B.1.429, 20C/452R
Epsilon
S13I, W152C, L452R
RVP-723
Nigerian/European variant B.1.525, 20A/484K
Eta
Q52R, ΔH69/V70, ΔY144, Q677H, F888L
RVP-724
South African variant Δ3 B.1.351, 20H/501Y.V2
Beta
L18F, D80A, D215G, ΔL242/A243/L244, R246I, K417N, N501Y, E484K, A701V
RVP-725
US variant N679S***
———
N679S
RVP-726
New York variant B.1.526, 20C/484K
Iota
L5F, T95I, D253G, E484K, A701V
RVP-727
Indian variant B.1.617, RBD mutations only (“double mutant”)
———
L452R, E484Q
RVP-736
Brazilian variant P.2
Zeta
E484K, V1176F, D614G
RVP-763
Indian variant B.1.617.2
Delta
T19R, G142D, del156/157, R158G, L452R, T478K, P681R, D950N
RVP-767
Columbia, B.1.621
Mu
T95I, Y144T, Y145S, ins146N, R346K,E484K, N501Y, P681H

Products in the above table require a 4 to 6 week lead time

* Described in Hodcroft et al., 2021

** Described in Hodcroft et al., 2020

***Identified in a newborn with high viral load (LoTempio et al., 2021)

Other Coronavirus RVPs

Catalog No.
Virus
Strain
RVP-801
SARS-CoV-1
Urbani
RVP-901
MERS-CoV HCoV-EMC (GFP only)
HCoV-EMC
RVP-920
229E
DQ243963.1
RVP-940
NL63
BBL54109

Control RVPs

Catalog No. (G/L)
RVP
Strain
RVP-1002
VSV with MLV core
Indiana

VSV with MLV RVPs can be used as a neutralization control with our transgenic ACE2 cells.

Influenza

For more information about these products, visit Influenza Reporter Viruses

Influenza A RVPs

Catalog No.
Virus (Subtype)
Strain Information
RVP-1201
Influenza A (H5N1)
Indonesia/5/05
RVP-1202
Influenza A (H3N2)
Darwin/9/2021
RVP-1204
Influenza A (H7N9)
Suzhou/3/2013
RVP-1205
Influenza A (H5N1)
Vietnam/1203/2004
RVP-1207
Influenza A (H5N1)
Vietnam/1194/2004
RVP-1208
Influenza A (H5N1)
turkey/Turkey/1/2005
RVP-1209
Influenza A (H5N8)
Astrakhan/3212/2020
RVP-1210
Influenza A (H7N9)
Guangdong/17SF003/2016
RVP-1211
Influenza A (H1N1)
Wisconsin/588/2019
RVP-1212
Influenza A (H3N2)
Darwin/6/2021
RVP-1213
Influenza A (H1N1)
Wisconsin/67/2022
RVP-1214
Influenza A (H5N1)
American Wigeon/SC/22-000345-001/2021
RVP-1215
Influenza A (H3N2)
Massachusettes/18/2022
RVP-1216
Influenza A (H3N2)
Thailand/8/2022

Influenza B RVPs

Catalog No.
Virus (Lineage)
Strain Information
RVP-1301
Influenza B (Victoria)
Washington/02/2019
RVP-1302
Influenza B (Victoria)
Austria/1359417/2021
RVP-1303
Influenza B (Yamagata)
Phuket/3073/2013

Filovirus

For more information about these products, visit Filovirus Reporter Viruses

Filovirus RVPs

Catalog No.
Virus
Strain
RVP-1401
Ebola
Mayinga/76
RVP-1501
Marburg
Uganda 2007

Henipavirus

Henipavirus RVPs

Catalog No.
Virus
Strain
RVP-1801
Nipah
Malaysia 2008

Arenavirus

Arenavirus RVPs

Catalog No.
Virus
Strain
RVP-1901
Lassa
Josiah

Arbovirus

For more information about these products, see the Dengue and Zika Reporter Virus case study

Arbovirus RVPs

Catalog No.
Virus
Strain
RVP-1101
Chikungunya Virus
S27
RVP-101
Dengue Virus 1
16007
RVP-201
Dengue Virus 2
16681
RVP-301
Dengue Virus 3
16562
RVP-401
Dengue Virus 4
TVP360
RVP-601
Zika Virus
SPH2015
RVP-1601
Yellow Fever Virus
Asibi
RVP-1603
Yellow Fever Virus
17D
RVP-1650
West Nile Virus
NY99

* For validation data, see Mattia et al., 2011

** For validation data, see Whitbeck et al., 2020

Integral Molecular’s RVPs are produced under stringent quality-controlled conditions

With two decades of virology experience, Integral Molecular is the industry leader in providing RVPs for applications including antibody R&D and serum screening for vaccine clinical trials

Frequently Asked Questions

RVPs incorporate virus-specific envelope proteins that are antigenically equivalent to those of live wild-type viruses. They contain a modified genome and so are replication-incompetent and safe to use under standard safety levels (BSL-2). Once the RVPs are in your hands, you can begin your neutralization assays immediately – no need for growing and sequencing live virus.
RVPs are used for infectivity and neutralization assays, and are ideal for use in high-throughput assay formats. They are a safe (BSL-2) and efficient alternative to live virus plaque or microneutralization assays. Many customers use our RVPs to conduct sera neutralization assays to assess efficacy of their vaccine or vaccine candidate.
Luciferase and GFP are used for quantitative readouts.

Integral Molecular offers many vaccine development solutions including the production of reporter viruses, epitope mapping on viral targets, protein engineering for vaccine discovery, and antibody discovery against viral targets.

We can produce custom RVPs to accelerate your vaccine or antibody development project, with variants of current RVPs, or for a virus of your choice. We have a team of expert scientists that acts as your partner from project initiation to delivery of RVPs. Our customized quality control services and reports meet the specific needs of your team and project.
We can produce large lots of RVPs to accommodate screening 100s or 1000s of samples in sera neutralization assays without bridging studies.

Integral Molecular does not work with any live viruses capable of causing infectious disease. We have developed Reporter Virus Particles (RVPs) to enable scientists to study viral components without the risk of exposure to viruses or the spread of contagious illnesses.

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