SOLUTIONS FOR VIROLOGY AND VACCINE DISCOVERY

Enabling the discovery of vaccines and antiviral therapeutics against SARS-CoV-2, dengue, Zika, and other viruses

Reporter Viruses

Epitope Mapping
MAb Specificity Testing

The most extensive catalog of Reporter Virus Particles (RVPs)

Reporter Virus Particles (RVPs) are replication-incompetent pseudovirus particles that enable safe (BSL-2), easy, and high-throughput viral infectivity and neutralization assays using standard detection instrumentation

SARS-CoV-2 RVPS and Variant Strains

SARS-CoV-2 Virus Strain/Isolate
RVP Catalog No.
Mutations
D614G
SARS-CoV-2
RVP-701
GenBank QHD43416.1
No
D614G
RVP-702
D614G
Yes
N439K
RVP-703
N439K
No
N439K/D614G
RVP-704
N439K
Yes
Danish/mink cluster 5
RVP-705
ΔH69/V70, Y453F, I692V, M1229I
No
UK variant (VUI 202012/01)
RVP-706
ΔH69/V70, ΔY144, N501Y, A570D, P681H, T716I, S982A, D1118H
Yes
Uk Variant (VUI 202012/01) with E484K
RVP-717
ΔH69/V70, ΔY144, E484K, N501Y, A570D, P681H, T716I, S982A, D1118H
Yes
South African variant (20C/501Y.V2)
RVP-707
L18F, D80A, D215G, L242H, R246I, K417N, N501Y, E484K, A701V
Yes
Japanese/Brazilian variant
RVP-708
L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, V1176F
Yes
E484K
RVP-709
E484K
Yes
N501Y (US/Ohio strain, COHD32 or COH.20g/501Y)
RVP-710
N501Y
Yes
S477N (Australian mutation, Hodcroft 2020
RVP-711
S477N
Yes
COHD15, US/Ohio strain
RVP-712
Q677H, L938F
Yes
452R variant (California)
RVP-713
S13I, W152C, L452R
Yes
South African variant (20H/501Y.V2)
RVP-714
L18F, D80A, D215G, ΔL242/A243, R246I, K417N, N501Y, E484K, A701V
Yes
South African RBD (K417N, E484K, N501Y)
RVP-715
K417N, E484K, N501Y
Yes
SARS-CoV-2 alanine mutant
Custom
1,200 ala-scan variants available
No
SARS-CoV-2 Custom strain/mutant
Custom
Custom

*Offerings updated weekly

Additional RVPS

Virus
Strain/Isolate
RVP Catalog No.
SARS-CoV-1
Urbani
RVP-801
MERS-CoV
HCoV-EMC
RVP-901
Dengue Virus 1
WestPac
RVP-101
Dengue Virus 2
S16803
RVP-201
Dengue Virus 3
CH53489
RVP-301
Dengue Virus 4
TVP360
RVP-401
Zika Virus
SPH2015
RVP-601

Integral Molecular’s RVPs are produced under stringent quality-controlled conditions

With two decades of virology experience, Integral Molecular is the industry leader in providing RVPs for applications including antibody R&D and serum screening for vaccine clinical trials

See RVP application notes

Cell Lines

Transgenes
Expression
Clonality
Origin Cell Line
Catalog No.
hsACE2
Stable
Monoclonal
HEK 293T
C-HA102
hsACE2, hsTMPRSS2
Stable
Monoclonal
HEK 293T
C-HA201

Frequently Asked Questions

Integral Molecular offers many vaccine development solutions including the production of reporter viruses, epitope mapping on viral targets, protein engineering for vaccine discovery and antibody discovery against viral targets.

RVPs incorporate virus-specific prM/E proteins and are antigenically equivalent to live wildtype viruses. They contain a modified RNA genome so they are safe and replication incompetent.

RVPs are useful for high-throughput infectivity and neutralization assays. They are an efficient alternative to plaque assays.

Luciferase or GFP is used for quantitative read out.

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