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REPORTER VIRUS PARTICLE CATALOG
Pseudotyped and pseudoinfective reporter viruses for
virology and vaccine discovery
Coronavirus | Influenza | Filovirus | Arbovirus | Henipavirus | Contact Us | FAQs
The most extensive catalog of Reporter Virus Particles (RVPs)
Reporter Virus Particles (RVPs) are replication-incompetent pseudovirus particles that enable safe (BSL-2), easy, and high-throughput viral infectivity and neutralization assays using standard detection instrumentation. To learn more about RVPs, visit Virology: Pseudotyped Reporter Virus Particles
We regularly add new products to our catalog. To receive updates on our product offerings, join our mailing list.
We also offer target cell lines, neutralizing antibodies, and control viral particles to use in your RVP research.
Coronavirus
Our extensive catalog of SARS-CoV-2 variants manufactured with rigorous quality control can help your discovery program meet FDA guidances for COVID-19 vaccines and therapeutics†
For more information about these products, visit SARS-CoV-2 Variant Reporter Viruses
Emergent Variant SARS-CoV-2 RVPs
Catalog No. (G/L*) | SARS-CoV-2 / Variant | WHO | Mutations |
|---|---|---|---|
RVP-701 | Wuhan-Hu-1 | ——— | Reference seq (GenBank QHD43416.1) |
RVP-702 | D614G B.1, 20A | ——— | D614G |
RVP-768 | B.1.1.529.1, BA.1 | Omicron | A67V, Δ69-70, T95I, G142D/Δ143-145, Δ211/L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F |
RVP-771 | B.1.1.529.1.1, BA.1.1 | Omicron | A67V, Δ 69-70, T95I, Δ 142-144, Y145D, Δ 211, L212I, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F |
RVP-770 | B.1.1.529.2, BA.2 | Omicron | T19I, Δ24-26, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K |
RVP-775 | B.1.1.529.2.12.1, BA.2.12.1 | Omicron | T19I, LPPA24S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452Q, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K |
RVP-776 | B.1.1.529.2.75, BA.2.75 | Omicron | T19I, LPPA24S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339R, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K |
RVP-774 | B.1.1.529.4/5, BA.4/BA.5 | Omicron | T19I, LPPA24S, HV69del, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K |
RVP-777 | B.1.1.529.4.6, BA.4.6 | Omicron | T19I, LPPA24S, HV69del, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, N764K, D796Y, Q954H, N969K |
RVP-779 | BF.7 | Omicron | T19I, LPPA24S, HV69del, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K |
RVP-785 | BQ.1 | Omicron | T19I, LPPA24S, HV69del, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K |
RVP-782 | BQ.1.1 | Omicron | T19I, LPPA24S, HV69del, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K |
RVP-787 | CH.1.1 | Omicron | T19I, LPPA24S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K |
RVP-780 | XBB.1 | Omicron | T19I, LPPA24S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K |
RVP-786 | XBB.1.5/XBB.1.9.1 | Omicron | T19I, LPPA24S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K |
RVP-789 | XBB.1.16 | Omicron | T19I, LPPA24S, V83A, G142D, Y144del, H146Q,E180V, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K |
RVP-790 | XBB.2.3 | Omicron | T19I, LPPA24S, V83A, G142D, Y144del, H146Q, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K |
RVP-788 | XBF | Omicron | T19I, LPPA24S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K |
RVP-763 | Indian variant B.1.617.2 | Delta | T19R, G142D, del156/157, R158G, L452R, T478K, P681R, D950N |
RVP-727 | Indian variant B.1.617, RBD mutations only (“double mutant”) | ——— | L452R, E484Q |
RVP-767 | Columbia, B.1.621 | Mu | T95I, Y144T, Y145S, ins146N, R346K,E484K, N501Y, P681H |
RVP-736
| Brazilian variant P.2
| Zeta
| E484K, V1176F, D614G
|
RVP-706 | UK variant B.1.1.7, 20I/501Y.V1 | Alpha | ΔH69/V70, ΔY144, N501Y, A570D, P681H, T716I, S982A, D1118H |
RVP-726 | New York variant
B.1.526, 20C/484K
| Iota | L5F, T95I, D253G, E484K, A701V |
RVP-723 | Nigerian/European variant
B.1.525, 20A/484K
| Eta | Q52R, ΔH69/V70, ΔY144, Q677H, F888L |
Catalog No. (G/L*) | SARS-CoV-2 / Variant | WHO | Mutations |
|---|---|---|---|
RVP-717 | UK variant B.1.1.7 with E484K | ——— | ΔH69/V70, ΔY144, E484K, N501Y, A570D, P681H, T716I, S982A, D1118H |
RVP-724 | South African variant Δ3
B.1.351, 20H/501Y.V2
| Beta | L18F, D80A, D215G, ΔL242/A243/L244, R246I, K417N, N501Y, E484K, A701V |
RVP-708 | Brazilian variant
P.1, 20J/501Y.V3
| Gamma | L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, V1176F |
RVP-713 | Californian variant
B.1.427/B.1.429, 20C/452R
| Epsilon | S13I, W152C, L452R |
*All RVPs are available with a GFP (G) or luciferase (L) reporter. Please add G/L to the catalog number when ordering to indicate the preferred reporter gene.
Custom SARS-CoV-2 RVP variants and RVPs from our library of 1,200 alanine spike mutants are available upon request. Please contact us for pricing.
†Learn more about how pseudoviruses meet FDA guidances
More SARS-CoV-2 Variant RVPs
Catalog No. (G/L) | SARS-CoV-2 RVPs / Variants | WHO | Mutations |
|---|---|---|---|
RVP-710 | US/Ohio strain, N501Y
20G/501Y
| ——— | N501Y |
RVP-711 | S477N (Australian/European variant)** | ——— | S477N |
RVP-712 | COHD15, US/Ohio variant | ——— | Q677H, L938F |
RVP-713 | Californian variant B.1.427/B.1.429, 20C/452R | Epsilon | S13I, W152C, L452R |
RVP-717 | UK variant B.1.1.7 with E484K | ——— | ΔH69/V70, ΔY144, E484K, N501Y, A570D, P681H, T716I, S982A, D1118H |
RVP-718 | Robin* 20G/677H | ——— | Q677H |
RVP-719 | Pelican* 20G/677P | ——— | Q677P |
RVP-721 | Quail* 20B/677H | ——— | Q677H, T732S |
RVP-722 | Mockingbird* 20A/677H | ——— | G142S, E180V, Q677H |
RVP-709 | E484K | ——— | E484K |
RVP-703 | N439K | ——— | N439K |
RVP-704 | N439K/D614G
20A/439K
| ——— | N439K |
RVP-705 | Danish mink “cluster 5” | ——— | ΔH69/V70, Y453F, I692V, M1229I |
RVP-725 | US variant N679S*** | ——— | N679S |
RVP-707 | South African variant
B.1.351, 20C/501Y.V2
| ——— | L18F, D80A, D215G, L242H, R246I, K417N, N501Y, E484K, A701V |
RVP-708 | Brazilian variant P.1, 20J/501Y.V3 | Gamma | L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, V1176Ft |
RVP-714 | South African variant Δ2
B.1.351, 20H/501Y.V2
| ——— | L18F, D80A, D215G, ΔL242/A243, R246I, K417N, N501Y, E484K, A701V |
RVP-724 | South African variant Δ3 B.1.351, 20H/501Y.V2 | Beta | L18F, D80A, D215G, ΔL242/A243/L244, R246I, K417N, N501Y, E484K, A701V |
Products in the above table require a 4 to 6 week lead time
* Described in Hodcroft et al., 2021
** Described in Hodcroft et al., 2020
***Identified in a newborn with high viral load (LoTempio et al., 2021)
Other Coronavirus RVPs
Catalog No. | Virus | Strain |
|---|---|---|
RVP-801 | SARS-CoV-1 | Urbani |
RVP-901 | MERS-CoV HCoV-EMC (GFP only) | HCoV-EMC |
RVP-920 | 229E | DQ243963.1 |
RVP-940 | NL63 | BBL54109 |
Control RVPs
Catalog No. (G/L) | RVP | Strain |
|---|---|---|
RVP-1002 | VSV with MLV core | Indiana |
VSV with MLV RVPs can be used as a neutralization control with our transgenic ACE2 cells.
Influenza
For more information about these products, visit Influenza Reporter Viruses
Influenza A RVPs
Catalog No. | Virus (Subtype) | Strain Information |
|---|---|---|
RVP-1201 | Influenza A (H5N1) | Indonesia/5/05 |
RVP-1202 | Influenza A (H3N2) | Darwin/9/2021 |
RVP-1204 | Influenza A (H7N9) | Suzhou/3/2013 |
RVP-1205 | Influenza A (H5N1) | Vietnam/1203/2004 |
RVP-1207 | Influenza A (H5N1) | Vietnam/1194/2004 |
RVP-1208 | Influenza A (H5N1) | turkey/Turkey/1/2005 |
RVP-1209 | Influenza A (H5N8) | Astrakhan/3212/2020 |
RVP-1210 | Influenza A (H7N9) | Guangdong/17SF003/2016 |
RVP-1211 | Influenza A (H1N1) | Wisconsin/588/2019 |
RVP-1212 | Influenza A (H3N2) | Darwin/6/2021 |
RVP-1213 | Influenza A (H1N1) | Wisconsin/67/2022 |
RVP-1214 | Influenza A (H5N1) | American Wigeon/SC/22-000345-001/2021 |
Influenza B RVPs
Catalog No. | Virus (Lineage) | Strain Information |
|---|---|---|
RVP-1301 | Influenza B (Victoria) | Washington/02/2019 |
RVP-1302 | Influenza B (Victoria) | Austria/1359417/2021 |
RVP-1303 | Influenza B (Yamagata) | Phuket/3073/2013 |
Filovirus
For more information about these products, visit Filovirus Reporter Viruses
Filovirus RVPs
Catalog No. | Virus | Strain |
|---|---|---|
RVP-1401 | Ebola | Mayinga/76 |
RVP-1501 | Marburg | Uganda 2007 |
Henipavirus
Henipavirus RVPs
Catalog No. | Virus | Strain |
|---|---|---|
RVP-1801 | Nipah | Malaysia 2008 |
Arbovirus
For more information about these products, see the Dengue and Zika Reporter Virus case study
Arbovirus RVPs
Catalog No. | Virus | Strain |
|---|---|---|
RVP-1101 | Chikungunya Virus
| S27 |
RVP-101
| Dengue Virus 1
| 16007
|
RVP-201
| Dengue Virus 2
| 16681
|
RVP-301 | Dengue Virus 3
| 16562
|
RVP-401
| Dengue Virus 4
| TVP360
|
RVP-601 | Zika Virus | SPH2015 |
RVP-1601 | Yellow Fever Virus | Asibi |
RVP-1603 | Yellow Fever Virus | 17D |
* For validation data, see Mattia et al., 2011
** For validation data, see Whitbeck et al., 2020
Integral Molecular’s RVPs are produced under stringent quality-controlled conditions
With two decades of virology experience, Integral Molecular is the industry leader in providing RVPs for applications including antibody R&D and serum screening for vaccine clinical trials
Frequently Asked Questions
Are RVPs the same as live virus?
RVPs incorporate virus-specific envelope proteins that are antigenically equivalent to those of live wild-type viruses. They contain a modified genome and so are replication-incompetent and safe to use under standard safety levels (BSL-2). Once the RVPs are in your hands, you can begin your neutralization assays immediately – no need for growing and sequencing live virus.
How are RVPs used?
RVPs are used for infectivity and neutralization assays, and are ideal for use in high-throughput assay formats. They are a safe (BSL-2) and efficient alternative to live virus plaque or microneutralization assays. Many customers use our RVPs to conduct sera neutralization assays to assess efficacy of their vaccine or vaccine candidate.
What is the RVP readout?
Luciferase and GFP are used for quantitative readouts.
What vaccine development services do you offer?
Integral Molecular offers many vaccine development solutions including the production of reporter viruses, epitope mapping on viral targets, protein engineering for vaccine discovery, and antibody discovery against viral targets.
Do you offer custom RVPs?
We can produce custom RVPs to accelerate your vaccine or antibody development project, with variants of current RVPs, or for a virus of your choice. We have a team of expert scientists that acts as your partner from project initiation to delivery of RVPs. Our customized quality control services and reports meet the specific needs of your team and project.
Do you offer large lots or volumes of RVPs?
We can produce large lots of RVPs to accommodate screening 100s or 1000s of samples in sera neutralization assays without bridging studies.
Integral Molecular does not work with any live viruses capable of causing infectious disease. We have developed Reporter Virus Particles (RVPs) to enable scientists to study viral components without the risk of exposure to viruses or the spread of contagious illnesses.
