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SOLUTIONS FOR VIROLOGY AND VACCINE DISCOVERY
Enabling the discovery of vaccines and antiviral therapeutics against SARS-CoV-2, dengue, Zika, and other viruses
The most extensive catalog of Reporter Virus Particles (RVPs)
Reporter Virus Particles (RVPs) are replication-incompetent pseudovirus particles that enable safe (BSL-2), easy, and high-throughput viral infectivity and neutralization assays using standard detection instrumentation
SARS-CoV-2 RVPS and Variant Strains
SARS-CoV-2 Virus Strain/Isolate | RVP Catalog No. | Mutations | D614G |
|---|---|---|---|
SARS-CoV-2 | RVP-701 | GenBank QHD43416.1
| No |
D614G | RVP-702
| D614G | Yes
|
N439K
| RVP-703
| N439K | No |
N439K/D614G
| RVP-704
| N439K
| Yes |
Danish/mink cluster 5
| RVP-705 | ΔH69/V70, Y453F, I692V, M1229I
| No |
UK variant (VUI 202012/01)
| RVP-706 | ΔH69/V70, ΔY144, N501Y, A570D, P681H, T716I, S982A, D1118H
| Yes |
Uk Variant (VUI 202012/01) with E484K | RVP-717 | ΔH69/V70, ΔY144, E484K, N501Y, A570D, P681H, T716I, S982A, D1118H | Yes |
South African variant (20C/501Y.V2)
| RVP-707
| L18F, D80A, D215G, L242H, R246I, K417N, N501Y, E484K, A701V
| Yes |
Japanese/Brazilian variant
| RVP-708
| L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, V1176F
| Yes |
E484K
| RVP-709
| E484K
| Yes |
N501Y (US/Ohio strain, COHD32 or COH.20g/501Y) | RVP-710
| N501Y
| Yes |
S477N (Australian mutation, Hodcroft 2020
| RVP-711
| S477N
| Yes |
COHD15, US/Ohio strain
| RVP-712
| Q677H, L938F
| Yes |
452R variant (California)
| RVP-713
| S13I, W152C, L452R
| Yes |
South African variant (20H/501Y.V2)
| RVP-714
| L18F, D80A, D215G, ΔL242/A243, R246I, K417N, N501Y, E484K, A701V
| Yes |
South African RBD (K417N, E484K, N501Y)
| RVP-715
| K417N, E484K, N501Y
| Yes |
SARS-CoV-2
alanine mutant
| Custom | 1,200 ala-scan variants available
| No |
SARS-CoV-2
Custom strain/mutant | Custom | Custom | — |
*Offerings updated weekly
Additional RVPS
Virus | Strain/Isolate | RVP Catalog No. |
|---|---|---|
SARS-CoV-1
| Urbani
| RVP-801
|
MERS-CoV | HCoV-EMC
| RVP-901
|
Dengue Virus 1
| WestPac
| RVP-101
|
Dengue Virus 2
| S16803
| RVP-201
|
Dengue Virus 3
| CH53489
| RVP-301 |
Dengue Virus 4
| TVP360
| RVP-401
|
Zika Virus | SPH2015 | RVP-601 |
Integral Molecular’s RVPs are produced under stringent quality-controlled conditions
With two decades of virology experience, Integral Molecular is the industry leader in providing RVPs for applications including antibody R&D and serum screening for vaccine clinical trials
Cell Lines
Transgenes | Expression | Clonality | Origin Cell Line | Catalog No. |
|---|---|---|---|---|
hsACE2 | Stable | Monoclonal | HEK 293T | C-HA102 |
hsACE2, hsTMPRSS2 | Stable | Monoclonal | HEK 293T | C-HA201 |
Frequently Asked Questions
Integral Molecular offers many vaccine development solutions including the production of reporter viruses, epitope mapping on viral targets, protein engineering for vaccine discovery and antibody discovery against viral targets.
RVPs incorporate virus-specific prM/E proteins and are antigenically equivalent to live wildtype viruses. They contain a modified RNA genome so they are safe and replication incompetent.
RVPs are useful for high-throughput infectivity and neutralization assays. They are an efficient alternative to plaque assays.
Luciferase or GFP is used for quantitative read out.
