The Bitter Taste Receptor TAS2R16 Achieves High Specificity and Accommodates Diverse Glycoside Ligands by using a Two-faced Binding Pocket
THOMAS ET AL. 2017. SCI REP 7, 7753-7768.
RESOURCES
Where research scientists come to find up to date resources on antibody discovery against challenging membrane protein targets.
Menu
Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices
WESCOTT ET AL. 2016. PNAS 113(35):9928-9933.
Screening the Membrane Proteome A High-Throughput Platform for Identifying Membrane Protein Antibody Targets
HUSTON-PATERSON ET AL. 2016. GENETIC ENGINEERING NEWS VOL. 36, NO. 15.
DNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops
VAN DER WONING ET AL. 2016. MABS 8(6):1126–1135.
i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4
GRIFFITHS ET AL. 2016. J BIO CHEM 291(24):12641-57.
A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs.
SANDAU ET AL. 2015. BMC NEUROSCIENCE 16(33):1-11.
Optimizing Membrane Protein Expression: Improving Surface Expression and Stability for Antibody and Vaccine Discovery.
DORANZ ET AL. 2015. GENETIC ENGINEERING NEWS VOL. 35, NO. 15.
TGP, an extremely stable, non-aggregating fluorescent protein created by structure-guided surface engineering.
CLOSE ET AL. 2015. PROTEINS 18(7):1225-1237
Exposure of epitope residues on the outer face of the chikungunya virus envelope trimer determines antibody neutralizing efficacy.
FONG ET AL. 2014. JOURNAL OF VIROLOGY 88(24):14364-14379.
Potent Dengue Virus Neutralization by a Therapeutic Antibody with Low Monovalent Affinity Requires Bivalent Engagement
EDELING ET AL. 2014. PLOS PATHOGENS 10(4):E1004072.
