We welcome partnerships with companies interested in developing highly differentiated preclinical antibodies into first-in-class therapeutics in the areas of oncology, immunity, metabolic disease, and pain.

Preclinical Pipeline

Preclinical Pipeline 2022

All antibody assets are exclusively owned by Integral Molecular and were discovered using our MPS Discovery platform.

Antibody Discovery for Membrane Protein Targets. It’s Not Impossible.

Multi-spanning membrane proteins are the targets of ~50% of all small-molecule drugs but only 3 therapeutic monoclonal antibodies (MAbs), due to the challenges of working with these complex proteins.

We are the industry leader in discovering antibodies against complex membrane protein targets, with a success rate of 95%. Our specialized technologies provide unprecedented access to an entire class of clinically important, yet untapped, targets.

MAb Discovery Partnerships

At Integral Molecular, we work with you to discover therapeutic MAbs against your targets by applying our expertise in membrane protein antibody discovery and target biology.

View more information on our MPS Antibody Discovery Platform

Target Discovery Partnerships

We have identified novel therapeutic targets using our breakthrough Membrane Proteome Array (MPA) platform. The MPA applies 6,000 human membrane proteins expressed in live human cells for binding and functional assays for new target discovery.

  • Immuno-oncology targets
  • Infectious disease targets
  • Alzheimer’s targets

View more information on the Membrane Proteome Array

Current Partnerships

Integral Molecular has provided an exclusive license to AstraZeneca for a collection of highly specific monoclonal antibodies for use in oncology, and to advance the goal of delivering personalized treatment. AstraZeneca is solely responsible for all research, development, and commercial activities to develop these therapeutics for multiple cancers.
Integral Molecular and Context Therapeutics are engaged in a research collaboration and licensing agreement for the development of an anti-claudin 6 (CLDN6) bispecific monoclonal antibody for gynecologic cancer therapy. Context Therapeutics is a clinical-stage women’s oncology company developing treatments for hormone-driven breast and gynecological cancers.
Integral Molecular has licensed a panel of Claudin 18.2 monoclonal antibodies to CARTEXELL, enabling CARTEXELL to develop CAR-T cell therapies. This exclusive worldwide license enables CARTEXELL to use Integral Molecular’s panel of high-affinity, high-specificity, and fully humanized Claudin 18.2 monoclonal antibodies to develop CAR-T cell therapies against solid tumors including gastric, lung, pancreatic, and esophageal cancers. CARTEXELL will be solely responsible for all research, development, and commercial activities.

Our research collaboration with Merus involves multiple undisclosed targets and leverages two of our proprietary technologies: MPS Antibody Discovery and Lipoparticles. Merus is a clinical-stage immuno-oncology company developing innovative bispecific antibody therapeutics.

This antibody discovery collaboration involves the discovery of candidate MAbs against an undisclosed target using our MPS Antibody Discovery platform. This collaboration, our second with Ono, is enabled by our proven success in isolating antibodies against multipass membrane proteins.` 

This target discovery collaboration leverages our Membrane Proteome Array platform to identify novel membrane proteins that regulate the immune system’s ability to recognize and destroy cancer cells. Daiichi Sankyo will use the identified immuno-oncology targets to develop new therapeutics.

Since 2009, our Shotgun Mutagenesis Epitope Mapping platform has been used to map 500+ epitopes for 1000+ mAbs against high-profile pathogenic viruses, including dengue, chikungunya, hepatitis C, Zika, and Ebola, as part of the B-Cell Epitope Discovery Program through the National Institute of Allergy and Infectious Diseases (NIAID) of the NIH.

Ready To Get Started?

Contact us to discuss licensing therapeutic assets or initiating a discovery partnership.

Or call (215) 966-6061