SARS-CoV-2 Reporter Virus Particle Offerings for Neutralization Assays
Integral Molecular offers quality-controlled SARS-CoV-2 reporter virus particles (RVPs) that enable safe (BSL-2), easy, and high-throughput viral infectivity and neutralization assays using standard detection instrumentation. RVPs are designed to be antigenically identical to wild-type viruses but with a modified genome that expresses a convenient optical reporter gene (GFP or luciferase) upon cellular infection. To assess the breadth of neutralization, we offer SARS-CoV-2 (Wuhan-Hu-1 and D614G), SARS-CoV-1 and MERS-CoV RVPs in addition to custom strains.
RVPs are available as validated, ready-to-use reagents that provide an efficient and safe (replication-incompetent) alternative to plaque assays. Dozens of commercial and academic laboratories use our RVP systems, for both R&D (e.g. for rapid testing of escape mutations and strain variants) and for serum sample testing (e.g. in vaccine clinical trials as critical reagents). As part of our commitment to supporting COVID-19 research, we are providing access to free SARS-CoV-2 RVP trial samples.