RECEPTORS
At Integral Molecular, we work with all major classes of integral membrane proteins, including G protein-coupled receptors (GPCRs) and ion channels. The table below represents some of the membrane proteins we have previously incorporated into Lipoparticles*. Nearly all membrane proteins tested to date can be incorporated into Lipoparticles, but surface expression of the membrane protein will influence incorporation levels.
| Class |
Relevance to Health |
#TMs |
Target Membrane Protein |
| GPCR |
HIV, Arthritis
HIV, Breast Cancer
Inflammation, angiogenesis
Neurological Control
Neurological Control
|
7
7
7
7
7 |
CCR5
CXCR4
CXCR3
Serotonin receptor (5HT1a)
Opioid receptor |
| Ion channel |
Neurological Control
Neurological Control
Cystic Fibrosis |
6
6
12 |
K channel (Human)
Shaker K channel (Drosophila)
CFTR receptor |
| Transporter |
Amino-acid transporter |
14 |
MCAT-1 |
| Multi-TM protein |
Alzheimer's disease |
6 |
Presenilin-1 receptor |
| Single TM |
HIV, Immune (T) cells
Angiogenesis
Cholesterol metabolism
Arthritis
Alzheimer's disease |
1
1
1
1
1 |
CD4
Neuropilin-1 (VEGF subtype)
Tva (LDL-receptor subtype)
Interleukin-5-α
BACE |
* This table does not represent a catalog
of currently available Lipoparticles. Lipoparticles
are custom produced with user-specified membrane proteins, and
are shipped to customers following QC and validation.
|
Email us the receptor you are interested in so we can test
it for incorporation into Lipoparticles: |
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