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Reporter Virus Particles (RVPs)

RVPs are replication-incompetent virus particles that enable viral infectivity studies to be conducted safely, easily, and reproducibly using standard detection instrumentation. RVPs express convenient optical reporter genes upon cellular infection and are offered as quality-controlled, ready-to-use reagents.

Dengue RVPs

Dengue RVPs retain antigenic equivalence to wild-type virions by incorporating specific prME proteins from Dengue serotypes 1, 2, 3, or 4. Dengue RVPs feature a luminescent reporter that provides a rapid and convenient read-out of infectivity, and are validated for both antibody neutralization and enhancement experiments.

HCV E2 core structures and mAbs: something is still missing.

Castelli, et al. 2014. Drug Discovery Today 19(12):1964-1970.

Membrane Protein Solutions for Antibody Discovery

Adam, et al. 2014. Genetic Engineering & Biotechnology News Vol. 34, No. 8.

Isolating Membrane Protein Antibodies.

Berdougo, et al. 2012. Genetic Engineering & Biotechnology News Vol. 33, No. 6.

High-throughput Alanine Scanning.

Berdougo and Doranz. 2012. Genetic Engineering & Biotechnology News Vol. 32, No. 12.

Maximal Humanization of Monoclonal Abs.

Berdougo, et al. 2011. Genetic Engineering & Biotechnology News Vol. 31, No. 14.

Antibodies against membrane protein targets.

Banik, et al. 2011. Genetic Engineering & Biotechnology News Vol. 31, No. 2.

Measuring membrane protein interactions using optical biosensors.

Rucker, et al. 2010. Methods in Molecular Biology 617:445-456.

Mapping complex antibody epitopes.

Banik and Doranz. 2010. Genetic Engineering & Biotechnology News Vol 30, No. 2.

Antibody strategies for membrane protein targets.

Banik and Doranz. 2009. Drug Discovery & Development Vol 12, No. 9.

Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes.

Chen, et al. 2010. The American Journal of Clinical Nutrition 90(3):7705-7795.

Tools for studying membrane protein targets.

Laing. 2009. Genetic Engineering & Biotechnology News Vol 29, No. 2.

Atomic-level mapping of antibody epitopes on a GPCR.

Paes, et al. 2009. Journal of the American Chemical Society 131(20):6952-6954.

Cell-free assay of G-protein couple receptors using fluorescence polarization.

Jones, et al. 2008. Journal of Biomolecular Screening 13(5):424-429.

Application Notes

Application Notes

  • Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice
  • Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection
  • Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices
  • Rapid isolation of dengue-neutralizing antibodies from single cell-sorted human antigen-specific memory B-cell cultures
  • Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress