Reporter Virus Particles (RVPs)
RVPs are replication-incompetent virus particles that enable viral infectivity studies to be conducted safely, easily, and reproducibly using standard detection instrumentation. RVPs express convenient optical reporter genes upon cellular infection and are offered as quality-controlled, ready-to-use reagents.
Dengue RVPs retain antigenic equivalence to wild-type virions by incorporating specific prME proteins from Dengue serotypes 1, 2, 3, or 4. Dengue RVPs feature a luminescent reporter that provides a rapid and convenient read-out of infectivity, and are validated for both antibody neutralization and enhancement experiments.